With a substantial amount of the National Institute of Health’s cannabinoid research budget being allocated to the study of the medical potential it provides. CBD and its benefits are being discovered nationwide for its medical use. Much of the research has centered on epilepsy and the potential CDB has for treating children with high doses. It’s been found that a 600 mg daily dosage reduces seizure frequency by 39%. While this is much more than you find in current CBD Products, the consumables available are geared toward anxiety, pain and other disorders.
Studies have discovered that low doses of CBD effectively treat anxiety, pain, and other disorders. But when applying higher doses the benefits for treating these symptoms disappears. So more CBD does not mean more relief the correct dosage should be applied for each treatment. Renowned cannabinoid pharmacologist Roger Pertwee described CBD actions at low, medium, and high doses in a review published in The British Journal of Pharmacology. As expected, low doses of CBD impact fewer neural targets than high doses. In relatively low doses, CBD can block endocannabinoids like anandamide and phytocannabinoids like delta 9-THC from interacting with receptors in the nervous system. This explains CBD’s ability to reduce the adverse effects that can accompany delta 9-THC exposure such as anxiety. CBD’s anti-anxiety effects can also be attributed to its activation and enhancement of specific serotonin receptors. Serotonin is an important neurotransmitter involved in mood regulation and stress response; low serotonin levels are thought to contribute to conditions including generalized anxiety disorder and major depression.
While CBD activation of 5-HT1a receptors is insufficient to protect against seizures, a promising target for CBD’s antiepileptic effects is the receptor GPR55, which initiates a cascade of events that can have diverse effects in brain cells. CBD is an antagonist of GPR55, blocking its function and altering brain activity in a way that may protect against seizures. When administered in higher doses, though, the benefits of lower concentrations may be lost. Anti-anxiety effects, for instance, seem to be obstructed while higher concentrations of CBD work to block GPR55 receptors.
Understanding CBD’s many neural targets and their sensitivity is an growing area of ongoing research. Knowing the optimal CBD dose for treating different conditions is a important component of successful CBD treatment. The current research suggests that anxiety and depression-related disorders respond best to low-moderate CBD doses, while epilepsy responds best to higher CBD doses.